Hello,If somebody running business in kathamandu, and client in USA how he/she can pay service fee to them eg I 20, I know paypal but some college may not accept it how to use master, visa from Nepal any expereince please share.........

How about Western Union Money Transfer ?
Can you also ask your client the different acceptable mode of payments ?

I guess there are several way sometime they call 'HUNDI', but they looking for cheapestway to pay the client (very low service fee/transaction fee etc.)...

Your University who issue I-20 have clear instruction on how to pay for it. You can better email them. They might tell you to transfer money through some bank account in Nepal. If you have any friends or relative in US, you might seek their help in paying through check or CC online payment. Hope that works. It's not a big deal. Sending email to admission officer will resolve your issue. Good Luck.

Interesting..usually its the client who pays.

Mancini is right. Question is confusing. Make it clear who needs to pay whom and for what.